Anemia and dysgeusia occurred more frequently in patients who received boceprevir. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection SPRINT-1 : an open-label, randomised, multicentre phase 2 trial. In both of the boceprevir regimens, patients received a 4-week lead-in treatment with peginterferon and ribavirin.
Boceprevir for untreated chronic HCV genotype 1 infection. Your Message:. Funded by. Created at University of Washington. Department of Medicine Gastroenterology. Overview Fingerprint.
Access to Document Link to publication in Scopus. Link to the citations in Scopus. This can happen decades after the initial infection. Amongst the symptoms that can develop with chronic liver damage, patients can suffer from inexplicable weight loss, pruritus, coagulation disorders that cause the patient to bleed and bruise easily, chronic fatigue, jaundice, ascites abdominal fluid buildup , swollen legs, spider angiomas spider-like blood vessels on the skin , hepatic encephalopathy slurred speech, confusion , vomiting blood hematemesis or melena caused by variceal bleeding , gynecomastia.
Tests are also carried out to determine the HCV genotype. The traditional regime to treat Hepatitis C includes pegylated interferon —also known as peginterferon- Pegasys and ribavirin Copegus. Treatment is usually started somewhere between 2 to 4 months after the onset of the disease, since there is a possibility of spontaneous viral clearance within 6 months of the infection.
Patients with advanced hepatic fibrosis, cirrhosis, severe extrahepatic symptoms, high-risk for complications and transmission of the disease are given priority for treatment. Treatment of Hepatitis C aims to eradicate the virus and to prevent the progression to cirrhosis or hepatocellular carcinoma. Newer medications include direct-acting antivirals DAAs and polymerase inhibitors, such as simeprivir, ledipasvir, elbasvir, grazoprevir, and sofosbuvir.
These medications have been approved for use after being tested in clinical trials, and can be given in combination with peginterferon and ribavirin, or by themselves.
Lijo John is a community pharmacist with 9 years of experience and graduated from Rutgers University in He has extensive experience serving patients with a focus in geriatric medicine, diabetes management, and preventative medicine such as immunizations and lifestyle modification counselling.
John also enjoys writing and presenting on complex medical topics aimed at the general population to drive positive behavioral change in topics such as vaccine hesitancy and smoking cessation. Hepatitis C HCV is an insidious and chronic infection that affects approximately 3. HCV is prevalent in high-risk populations such as injectable drug users, the homeless and prisoners.
Most acute HCV infections are asymptomatic, which means there is usually significant disease progression before it is diagnosed. Almost all patients with HCV infection are recommended for treatment, and the treatment goal is to cure the disease.
Sustained virological response SVR is defined as no detectable viral load 12 weeks or later post completion of therapy. This therapy also had a significant side effect profile such as flu-like symptoms, neuropsychiatric symptoms like depression and irritability, as well as possible autoimmune exacerbations. For every trial, there is a document we will read through with you that details all the important information we have that you need to know about the drug and the trial.
We call this document "Informed Consent" and it tells you everything that will be asked of you in the trial; it is usually 25 pages long. Before you agree to be in the trial, you should take the document home to read at your leisure and discuss with your advisors and your doctor.
Some Hepatitis C trials have an initial placebo arm to identify side effects patients on active drug have versus patients on placebo. This is to determine side effects that are likely related to the study drug versus side effects that are not related to the study drug.
Patients initially assigned to a placebo arm will receive active medication after the conclusion of the initial study arm.
No, you don't have to have a liver biopsy to be in a Hepatitis C clinical trial. But you may need a special test of your liver called a Fibroscan. A Fibroscan is like an ultrasound. Instead of needles into the liver, we use the Fibroscan to send sound waves and the information back tell us the condition of your liver: whether it is soft and floppy like a normal healthy liver or less flexible like we see in conditions like cirrhosis.
The test is easy to perform and we do it right here in the office. It takes about 10 minutes to do and is painless. The Fibroscan is new to the US and because of this, we rarely need biopsies anymore. No you do not pay anything to be in an interferon free clinical trial. In a clinical trial, the medications and procedures you need for the trial are provided at no charge. When you are in a Hepatitis C clinical trial, there are frequent office visits especially at the beginning of the trial.
In the first three months of many trials, there can be as many as 9 visits. Once you are on the trial, each visit takes about an hour. Most trials provide a stipend or payment to the patient to assist with the cost of travel, such as gas, taxi or parking.
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